Mountain Valley MD Announces Results From Cold Chain Storage Evaluation of Novel Quicksome™ Technology
Mountain Valley MD Holdings Inc. (CNSX:MVMD) (OTCMKTS:MVMDF) is pleased to announce the results of its recent controlled cold chain evaluation of the Company’s Quicksome™ desiccated liposome technology.
The controlled cold chain evaluation was the Company’s first attempt at assessing the ability of a thin Quicksome™ desiccated liposome layer of Trivalent Inactivated Poliovirus Vaccine (tIPV), using a method of preservation in a vial for five days of exposure at 40 degrees Celsius and then reconstituted for injection at the point of administration.
CONTROLLED COLD CHAIN TESTING RESULTS:
The trivalent IPV stability evaluation was conducted to assess the preservation application of MVMD’s Quicksome™ technology after 5 days exposure to 40 degrees Celsius. Trivalent IPV is composed of three serotypes of inactivated polioviruses.
IPV serotype two – achieved 100% preservation and stability.
IPV serotypes one and three achieved 50% preservation and stability.
The 100% preservation and stability of IPV serotype two exceeds the World Health Organization’s (WHO) guideline temperature requirements for all three defined vaccine management categories* including traditional cold chain between +2°C and +8°C, Extended Controlled Temperature Conditions (ECTC) above +8°C for a specified number of days to support vaccine distribution, and Controlled Temperature Chain (CTC) where the vaccine must be able to tolerate ambient temperatures of at least +40°C for a minimum of 3 days.
IPV serotypes one and three will be the focus of the next phase of evaluation the Company will conduct by focusing on lowering residual moisture content, achieving more robust liposomal protection, and faster drying of the mixture within the vial. The Company’s objective is to achieve full CTC compliance at 40°C for tIPV polio vaccines in a vial format that can be reconstituted at the point of administration for injection and is immediately commencing this work.
As announced in the Company’s news release dated June 24, 2021, MVMD has formally entered into a two-year collaborative research agreement with the Food and Drug Administration (“FDA”). The collaborative research agreement will support the continuation of research, development, and evaluation of the Company’s Quicksome™ controlled cold chain technology.
“The validation of Mountain Valley MD’s Quicksome™ technology supports our exploration around the ability to transport and store the polio vaccine outside of the traditional cold chain system,” stated Mike Farber, Director of Life Sciences for Mountain Valley MD. “While we will immediately pursue our goal of 100% preservation of trivalent IPV, our initial preservation achievement of IPV serotype two we believe is a proxy that we can apply to other vaccines in the future.”
Cold chain is a temperature-controlled supply chain that prescribes necessary conditions during the transport, storage, and handling of vaccines to preserve a temperature range between +2°C and +8°C from the time the vaccine is produced until it is administered. Current estimates place cold chain biopharma logistics spending for 2020 at USD $17.2 billion annually**, with costs due to failures in temperature-controlled logistics estimated at approximately USD $35 billion per year, and in most cases representing over half of a vaccine’s cost.*** The WHO estimates that more than 50% of vaccines are wasted globally every year due to temperature control, logistics and shipment-related issues.****
MVMD’s Quicksome™ technology has taken an important step forward in our pursuit to change the global vaccination landscape and provide more certainty of vaccine distribution to the most disadvantaged communities in the world. With the planned work in the coming months on our tIPV project, we feel our Quicksome™ technology is progressing positively towards our vision of reducing the complexity, wastage and significant costs associated with cold chain distribution.Dennis Hancock, President and CEO of Mountain Valley MD
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