Clearmind Medicine Launches Trial for Alcoholism

The TDR Three Takeaways for Clearmind:

1. Clearmind Medicine receives approval for a groundbreaking clinical trial on psychedelic therapy for alcoholism, marking a significant advancement.
2. The trial aims to evaluate the safety, efficacy, and pharmacokinetics of CMND-100 in treating alcohol use disorder, showcasing potential innovation.
3. Clearmind Medicine’s focus on non-hallucinogenic psychedelic solutions presents a promising direction for alcoholism treatment research.

Clearmind Medicine (Nasdaq: CMND) a Vancouver-based biotech firm, has achieved a milestone with the Israeli Ministry of Health’s approval to start a phase I/IIa clinical trial targeting alcohol use disorder (AUD) with its compound, CMND-100. This approval heralds Clearmind’s entry into clinical-stage research, focusing on psychedelic-derived therapeutics for treating significant health challenges like alcoholism.

The clinical trial is designed as a multinational, multi-center study, scrutinizing the tolerability, safety, and pharmacokinetics of CMND-100, a drug based on 5-methoxy-2-aminoindane (MEAI). MEAI stands out for its non-hallucinogenic properties, aiming to reduce alcohol consumption by inducing a mild euphoria similar to the effects of alcohol, without the addictive downsides. The trial will span sites in Israel, including the Sheba Medical Center, as well as prominent institutions in the United States like Yale School of Medicine and Johns Hopkins University.

At the heart of Clearmind’s research is the potential of psychedelic compounds to offer new solutions to addiction. CMND-100’s development reflects a broader shift in how the medical community approaches the treatment of AUD, focusing on underlying neurochemical pathways rather than solely on symptoms or behavior modification. The active ingredient, MEAI, interacts with several key receptors and transporters in the brain, including serotonergic and alpha-2-adrenergic receptors, which play crucial roles in alcohol intake regulation and the reward system.

This trial’s primary objective is to establish a tolerable dose range for CMND-100 and to detail its safety profile and pharmacological effects in both healthy volunteers and AUD patients. A secondary aim is to assess preliminary efficacy in reducing alcohol consumption and craving in subjects with moderate-to-severe AUD. This approach not only promises to advance our understanding of AUD treatments but also highlights the therapeutic potential of psychedelics in a controlled, non-hallucinogenic form.

Clearmind Medicine’s commitment to exploring psychedelic-based treatments for addiction and other under-addressed health issues is supported by their intellectual property portfolio, encompassing fifteen patent families. As the company progresses from preclinical to clinical stages, its efforts could significantly influence the future  of addiction treatment, providing hope for individuals struggling with alcohol use disorder. Want to keep up to date with all of TDR’s research and news, subscribe to our daily Baked In newsletter.