Cybin’s Leap Forward: DMT-Based Therapy Ready for Phase 2 Trials

The TDR Three Key Takeaways

  1. Innovative DMT-Based Therapies: Cybin Inc. is evolving psychedelic therapy with CYB004 and SPL028, derived from DMT. These therapies are significant as they offer strong psychedelic effects at much lower doses than traditional DMT, reducing potential side effects and increasing accessibility for patients.
  2. Shorter Duration, Greater Convenience: A key advancement of CYB004 and SPL028 is their short-acting nature, contrasting with traditional psychedelics like psilocybin and MDMA which require lengthy sessions. This shorter duration allows for more convenient and less time-consuming therapy sessions, particularly beneficial for those new to psychedelic therapy or with limited time.
  3. Enhanced Safety and Predictability: The pharmacokinetic (PK) and pharmacodynamic (PD) profiles of these new therapies ensure effective therapeutic concentrations are quickly achieved and maintained safely. This leads to a more predictable and safer therapeutic experience, marking a significant step forward in patient-friendly mental health treatments and moving Cybin closer to Phase 2 trials.

Cybin (NYSE American: CYBN, NEO: CYBN)  is working to solve one of the primary challenges in psychedelic therapy is managing the duration and intensity of the experience. Traditional therapies using substances like psilocybin and MDMA often require a significant portion of the day, requiring a substantial commitment in terms of time and professional involvement. This can make such treatments costly and logistically challenging. In addition, the profound depth of these psychedelic experiences can be mentally and physically taxing, especially for first-timers.

DMT, known for its intense yet brief psychedelic effects, presents an alternative. However, it too comes with its challenges, mainly concerning the dosage needed to achieve desired therapeutic effects, which can raise side effects concerns. Cybin Inc., in its Phase 1 trials, is addressing these issues head-on with two innovative medicines derived from DMT, named CYB004 and SPL028.

Cybin’s research marks a significant advancement in the field of psychedelic therapy. CYB004, in particular, has shown the potential to induce strong psychedelic effects at much lower doses compared to traditional DMT. This reduced dosage not only minimizes potential side effects but also makes the therapy more accessible and manageable for patients.

Another notable development is the duration of the psychedelic experience with CYB004 and SPL028. Unlike traditional psychedelic sessions that can last several hours, these new forms are short-acting. This shorter duration means that patients can undergo therapy in a much more convenient and less time-intensive manner. It’s a promising development for those new to psychedelic therapy or those with limited time availability. DMT experiences have been noted to be less than one hour in duration.

The pharmacokinetic (PK) and pharmacodynamic (PD) profiles of CYB004 and SPL028 further enhance their appeal. PK deals with how a drug is absorbed, distributed, metabolized, and excreted by the body, while PD focuses on the drug’s biochemical and physiological effects. Both CYB004 and SPL028 have shown effective therapeutic concentrations that are quickly achieved and maintained safely and comfortably for patients. This efficiency in processing means a safer, more predictable therapeutic experience.

This development builds upon the positive news from November about Cybin’s Phase 2 study of CYB003 for major depressive disorder.

Potentially, Cybin is making DMT treatments not just more manageable in dosage and duration but also safer and more controlled for patients. This significant advancement opens new doors to accessible and patient-friendly options in mental health care, ready to move into the transformative phase of Phase 2 trials. We will be closely watching this development at TDR and will be considering adding Cybin as a candidate for full research coverage.

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